Buy J147 10mg

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J-147 is and anti-aging nootropic supplement that has both neuroprotective and neurogenic properties. It enhances cognition without affecting the acetylcholine or phosphodiesterase enzymes.

For Research Purposes Only

  • 60 tabs per bottle
  • 10mg per tab

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Product Details

J-147 – The Anti-Aging Nootropic?

As you take a deep dive into the world of nootropics, you begin to see that not all nootropics are created with equal benefits and applications. For example, some might promote sleep or relieve anxiety, while others act as stimulants or provide laser focus. Even then, they will act on different neurotransmitters such as dopamine, adrenaline, or serotonin ro name a few so truly this is a category with a vast scope. However, one relatively new frontier in the field is looking at their anti-aging effects.

After puberty, the brain is fully developed and ages from this point onwards. The point of actual decline may begin in your 20s or 30s in some individuals. This can be accelerated or slowed by the lifestyle choices we make, such as alcohol, drugs, sleep, and stress. While cycloastragenol is highly regarded in the anti-aging field for its ability to combat inflammation and age related shortening of telomeres, this is only one of the ways in which aging causes a deterioration in physical and cognitive status.

One new compound which has been investigated as a potential anti-aging compound is J-147 and it works in a completely different way to cycloastragenol. Here’s what we know about it so far.

What is J-147 and how does it work?

J-147 is derived from curcumin, the active ingredient in turmeric. Unlike curcumin, it can cross the blood-brain barrier very successfully.

J-147 works by binding to ATP synthase. The overproduction of ATP has links to the aging process. J-47 can control this in addition to increasing levels of the neurotransmitters NGF and BDNF.

Several studies with J-147 have been conducted in mice. A human trial was carried out in 2020, however, full results have not yet been shared.

J-147 and Dementia

Mice with rapidly aging brains were treated with CMS121 and J147. The researchers found that it reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. Both compounds preserved mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS121 and J147 increased the levels of acetyl-CoA in cell culture and mice via the inhibition of acetyl-CoA carboxylase 1 (ACC1), resulting in neuroprotection and possible memory enhancement. [1]

Another mouse study found that, by targeting ATP synthase, J147 causes an increase in intracellular calcium leading to sustained calcium/calmodulin-dependent protein kinase β (CAMKK2)-dependent activation of the AMPK/mTOR pathway, a canonical longevity mechanism. [2]

J-147 and Diabetic Neuropathy

Diabetic peripheral neuropathy is a condition where nerve damage occurs as a result of chronically raised blood glucose levels, as can be seen in poorly managed diabetes. J-147 may help treat this complication.

In rats, it was concluded that J147 could ameliorate DPN via negative regulation AMPK on TRPA1 in vivo and in vitro. J147 has been suggested as an alternative to the polypharmaceutical approaches required to treat the multiple pathogenic mechanisms that contribute to diabetic neuropathy. [3][4]

J-147 and Depression

J-147 has been investigated for anti-depressant-like effects. This seems to work through 5-HT 1A-mediated cAMP signaling, with improvements seen in rats in just 3 days. In another rat study, up-regulated pCREB and BDNF levels lasted for 3h after 10 mg/kg of J147. [5][6]

Benefits of J-147

  • Improves mitochondrial function and longevity
  • Improves memory and cognition
  • May help neurogenesis
  • Might improve anxiety symptoms

J-147 Risks and Side Effects

J-147 successfully passed the toxicology testing in animal trials as required by the Food and Drug Administration (FDA), and no negative effects have been reported in humans when taken at an appropriate dosage (discussed later).

These are sold for laboratory research only. The description above is not medical advice and is for informative purposes only.

IDRA-21 is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses.

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